Release 55
(Dec 23, 2024)

Whole genome analysis for QTL/association enrichment

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Version: Enrich S: beta v0.8
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Data:

Number of disease & injury traits:19
Number of QTL / associations found:1,186
Number of chromosomes where QTL / associations are found:32

Chi-squared (χ2) test: are disease & injury traits over-represented on some chromosomes?

Chromosomes Total χ2 df p-values FDR * Size of χ2
Chromosome X375.45235318.862101e-612.578066e-60
Chromosome 19196.51471319e-411.694118e-40
Chromosome 2183.85027311.247143e-231.995429e-23
Chromosome 314115.88052319e-411.694118e-40
Chromosome 432.29886310.40237264.952278e-01
Chromosome 551.90762310.010704481.370173e-02
Chromosome 6149.24652312.067906e-173.007863e-17
Chromosome 74.42358310.9983293258231159.987273e-01
Chromosome 8206.34266318.511906e-281.433584e-27
Chromosome 9167.25320311.29424e-201.972175e-20
Chromosome 102.18082310.9983293258231159.987273e-01
Chromosome 114.80814310.9983293258231159.987273e-01
Chromosome 12463.30721311.539531e-786.158124e-78
Chromosome 134.80814310.9983293258231159.987273e-01
Chromosome 1413.13869310.9979369.987273e-01
Chromosome 153113.95142319e-411.694118e-40
Chromosome 165327.05090319e-411.694118e-40
Chromosome 17249.53327315.448514e-369.686247e-36
Chromosome 1812.49782310.99872739.987273e-01
Chromosome 19432.99689312.213772e-727.084070e-72
Chromosome 20101.37811312.110201e-092.813601e-09
Chromosome 21322.00877313.90565e-509.613908e-50
Chromosome 22432.99689312.213772e-727.084070e-72
Chromosome 23322.00877313.90565e-509.613908e-50
Chromosome 24630.23817317.395319e-1132.366502e-111
Chromosome 25527.00376311.457459e-911.554623e-90
Chromosome 26116.30888318.450996e-121.175791e-11
Chromosome 27463.30721311.539531e-786.158124e-78
Chromosome 28463.30721311.539531e-786.158124e-78
Chromosome 29463.30721311.539531e-786.158124e-78
Chromosome 30463.30721311.539531e-786.158124e-78
Chromosome 31527.00376311.457459e-911.554623e-90

Chi-squared (χ2) test: Which of the 19 disease & injury traits are over-represented in the QTLdb

Traits Total χ2 df p-values FDR * Size of χ2
Bone fracture 362.36071 18 6.212093e-66 2.360595e-65
Dwarfism 38.94884 18 0.002895063 3.055900e-03
Equine arteritis virus 643.76468 18 4.733995e-125 8.994591e-124
Equine metabolic syndrome 82.61048 18 2.981681e-10 3.332467e-10
Equine neuroaxonal dystrophy/degenerative myeloencephalopathy 366.31793 18 9.363992e-67 4.447896e-66
Equine sarcoids 126.19952 18 2.809333e-18 3.558488e-18
Foal Immunodeficiency Syndrome 158.72728 18 1.478238e-24 2.340543e-24
Guttural pouch tympany 632.57965 18 1.104906e-122 1.049661e-121
Hydrocephalus 549.50041 18 3.947031e-105 2.499786e-104
Insect bite hypersensitivity 189.06939 18 1.517964e-30 2.621938e-30
Laminitis 36.0625 18 0.006927053 6.927053e-03
Osteochondrosis 141.7974 18 2.882840e-21 4.213382e-21
Osteochondrosis dissecans 258.76883 18 1.336857e-44 4.233380e-44
Recurrent airway obstruction 190.60825 18 7.498075e-31 1.424634e-30
Recurrent exertional rhabdomyolysis 192.9005 18 2.619787e-31 5.530661e-31
Recurrent laryngeal neuropathy 119.15679 18 6.053312e-17 7.188308e-17
Recurrent uveitis 134.46948 18 7.406561e-20 1.005176e-19
Rhodococcus equi infection 195.78362 18 6.969216e-32 1.655189e-31
chronic progressive lymphedema 220.80274 18 6.666742e-37 1.809544e-36

Correlations found between some of these traits for your reference

No correlation data found on these traits

Overall Test

Data Chi'Square Test Fisher's Exact Test
Number of chrom.:32 χ2=38939.619540
Number of traits:19 df=558
Number of QTLs:1,186 p-value=0

FOOT NOTE: * : FDR is short for "false discovery rate", representing the expected proportion of type I errors. A type I error is where you incorrectly reject the null hypothesis, i.e. you get a false positive. It's statistical definition is FDR = E(V/R | R > 0) P(R > 0), where V = Number of Type I errors (false positives); R = Number of rejected hypotheses. Benjamini–Hochberg procedure is a practical way to estimate FDR.

 

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