| QTL Map Information |
|---|
| Chromosome: | 14 |
| QTL Peak Location: | 0.00 (cM) |
| QTL Span: | 0.00-0.00 (cM)
39.6-39.8 (Mbp) |
 |
Upper, "Suggestive": | n/a |
| Upper, "Significant": | n/a |
| Peak: | rs331907570 |
| Lower, "Significant": | n/a |
| Lower, "Suggestive": | n/a |
| Marker type: | SNP |
| Analysis type: | Association |
| Model tested: | Mendelian |
| Test base: | Comparison-wise |
| Threshold significance level: | Significant |
 |
P_values | 3.98E-5 | | Dominance effect: | n/a |
| Additive effect: | n/a |
| Associated Gene: | LIMK2 (LIM domain kinase 2) |
| Cis/Trans acting type: |  |
| Links:
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| Extended information: |
|---|
| (none) |
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| QTL Experiment in Brief |
|---|
| Animals: | Animals were from a backcross between MeLiM (porcine model of spontaneous melanoma) and Duroc pigs. |
| Breeds associated:
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| Design: | Animals were genotyped using the Illumina PorcineSNP60 BeadChip v1 and analyzed for melanoma phenotypes. A total of 47,536 SNPs were used for analysis. |
| Analysis: | Mixed models based on a maximum likelihood approach were used. |
| Software: | QxPAK |
| Notes: | |
| Links: | Edit |
| Reference |
|---|
| Authors: | Bourneuf E, Estellé J, Blin A, Créchet F, Schneider MDP, Gilbert H, Brossard M, Vaysse A, Lathrop M, Vincent-Naulleau S, Demenais F |
| Affiliation: | CEA, DRF/iRCM/SREIT/LREG, Jouy-en-Josas, France; GABI, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France |
| Title: | New susceptibility loci for cutaneous melanoma risk and progression revealed using a porcine model |
| Journal: | Oncotarget, 2018, 9(45): 27682-27697 |
| Links: |
PubMed | Abstract | List all data
| Edit |
| Additional Information |
|---|
| Comments: | melanoma occurrence |
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